Overview

  • Product nameAnti-MFSD8 antibody
  • Description
    Rabbit polyclonal to MFSD8
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 351-400 (FFILLPWGNQ FPKIQWEDLH NNSIPNTTFG EIIIGLWKSP MEDDNERPTG) of human MFSD8 (NP_689991).

  • Positive control
    • HepG2 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab108231 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionMay be a carrier that transport small solutes by using chemiosmotic ion gradients.
  • Tissue specificityExpressed at very low levels in all tissues tested.
  • Involvement in diseaseDefects in MFSD8 are the cause of neuronal ceroid lipofuscinosis type 7 (CLN7) [MIM:610951]. A form of late infantile neuronal ceroid lipofuscinosis. CNL are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by the intracellular accumulation of autofluorescent lipopigment storage material in different patterns ultrastructurally. The patterns most often observed CLN7 are mixed combinations of granular, curvilinear, fingerprint, and rectilinear profiles. The clinical course includes progressive dementia, seizures, and progressive visual failure.
  • Sequence similaritiesBelongs to the major facilitator superfamily.
  • Cellular localizationLysosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ceroid-lipofuscinosis neuronal protein 7 antibody
    • CLN7 antibody
    • Major facilitator superfamily domain-containing protein 8 antibody
    • MFSD8 antibody
    • MFSD8_HUMAN antibody
    see all

Anti-MFSD8 antibody images

  • Anti-MFSD8 antibody (ab108231) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 57 kDa

References for Anti-MFSD8 antibody (ab108231)

ab108231 has not yet been referenced specifically in any publications.

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