Overview

  • Product name
    MI-192 hydrochloride
  • Description
    Selective HDAC2/3 inhibitor
  • Biological description
    Selective HDAC2/3 inhibitor. Regulates cytokine production from rheumatoid arthritis peripheral blood mononuclear cells (PBMCs). Shows anticancer effects in vitro.
  • Purity
    > 98%
  • General notes

    Sold under license from CRT.

Properties

  • Chemical name

    N-(2-Aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]benzamide hydrochloride

  • Molecular weight
    419.91
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C24H21N3O2.HCl
  • CAS Number
    1415340-63-4
  • PubChem identifier
    56965342
  • Storage instructions
    Store at -20°C (desiccating conditions).
  • Solubility overview

    Soluble in DMSO to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    Cl.Nc4ccccc4NC(=O)c1ccc(cc1)CN2CC(=C)c3ccccc3C2=O
  • Source

    Synthetic

References

This product has been referenced in:
  • Gillespie J  et al. Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Rheum 64:418-22 (2012). Read more (PubMed: 21952924) »
  • Boissinot M  et al. Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk Res 36:1304-10 (2012). Read more (PubMed: 22818799) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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