Overview

  • Product nameMibefradil dihydrochloride
  • Description
    Ca2+ channel blocker
  • Biological descriptionCa2+ channel blocker. Shows moderate selectivity for T-type channels (IC50 values are 2.7 and 18.6 μM for T-type and L-type respectively). Shows antihypertensive effects in vivo. Orally active.
  • Purity> 98%

Properties

  • Chemical name(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetate dihydrochloride
  • Molecular weight568.56
  • Chemical structureChemical Structure
  • Molecular formulaC29H38FN3O3.2HCl
  • CAS Number116666-63-8
  • Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.Cl.CC(C)[C@H]4c5ccc(F)cc5CC[C@]4(OC(=O)C1CC1)CCN(C)CCCc2nc3ccccc3n2
  • Source

    Synthetic

  • Research areas

    References for Mibefradil dihydrochloride (ab120343)

    This product has been referenced in:
    • Wang J  et al. Ca(2+) influx mediates the TRPV4-NO pathway in neuropathic hyperalgesia following chronic compression of the dorsal root ganglion. Neurosci Lett 588:159-65 (2015). Read more (PubMed: 25575793) »
    • Fernández-Morales JC  et al. Blockade by NNC 55-0396, mibefradil, and nickel of calcium and exocytotic signals in chromaffin cells: implications for the regulation of hypoxia-induced secretion at early life. Eur J Pharmacol 751:1-12 (2015). Read more (PubMed: 25622555) »
    • Osterrieder W & Holck M In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action. J Cardiovasc Pharmacol 13:754-9 (1989). Read more (PubMed: 2472524) »

    See all 3 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120343.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"