Overview

  • Product name
  • Description
    Mouse polyclonal to MICB
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein corresponding to amino acids 1-340 of Human MICB (AAH44218.1).

  • Positive control
    • MICB transfected 293T cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab167488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa.

Target

  • Function
    Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
  • Tissue specificity
    Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
  • Involvement in disease
    Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=The MICB*004 allele is associated with rheumatoid arthritis.
    Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
  • Sequence similarities
    Belongs to the MHC class I family. MIC subfamily.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Post-translational
    modifications
    Proteolytically cleaved and released from the cell surface of tumor cells.
  • Cellular localization
    Cell membrane. Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • MHC class I chain related protein B antibody
    • MHC class I chain related protein B2 antibody
    • MHC class I like molecule PERB11.2 IMX antibody
    • MHC class I mic B antigen antibody
    • MHC class I polypeptide related sequence B antibody
    • MHC class I polypeptide-related sequence B antibody
    • MIC B antibody
    • MIC-B antibody
    • MICB antibody
    • MICB_HUMAN antibody
    • PERB11.2 antibody
    • Stress inducible class I homolog antibody
    see all

Images

  • All lanes : Anti-MICB antibody (ab167488) at 1 µg/ml

    Lane 1 : MICB transfected 293T cell lysate

    Lane 2 : Non-transfected 293T cell line lysate


    Lysates/proteins at 15 µl per lane.

    Developed using the ECL technique.

    Predicted band size: 43 kDa

References

ab167488 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab167488.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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