Anti-MICB antibody [MM0473-3C37] (ab90237)

Overview

  • Product name
    Anti-MICB antibody [MM0473-3C37]
    See all MICB primary antibodies
  • Description
    Mouse monoclonal [MM0473-3C37] to MICB
  • Tested applications
    Suitable for: WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human MICB.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • Clonality
    Monoclonal
  • Clone number
    MM0473-3C37
  • Isotype
    IgG2b
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 43 kDa.
Flow Cyt 1/20 - 1/200. ab170192-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

Target

  • Function
    Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
  • Tissue specificity
    Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
  • Involvement in disease
    Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=The MICB*004 allele is associated with rheumatoid arthritis.
    Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
  • Sequence similarities
    Belongs to the MHC class I family. MIC subfamily.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Post-translational
    modifications
    Proteolytically cleaved and released from the cell surface of tumor cells.
  • Cellular localization
    Cell membrane. Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • MHC class I chain related protein B antibody
    • MHC class I chain related protein B2 antibody
    • MHC class I like molecule PERB11.2 IMX antibody
    • MHC class I mic B antigen antibody
    • MHC class I polypeptide related sequence B antibody
    • MHC class I polypeptide-related sequence B antibody
    • MIC B antibody
    • MIC-B antibody
    • MICB antibody
    • MICB_HUMAN antibody
    • PERB11.2 antibody
    • Stress inducible class I homolog antibody
    see all

References

ab90237 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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For GLIPR1, the immunogen for ab118382 is 97% homologous with XP_001117594 - the predicted protein sequence for Macaca mulatta. We would predict this antibody to work for monkey samples.

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