Overview

  • Product name
    Anti-MIIP antibody
  • Description
    Mouse polyclonal to MIIP
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-388 of Human MIIP (AAH08068.1).

  • Positive control
    • Lysate of 293T cells transfected with MIIP.

Properties

Applications

Our Abpromise guarantee covers the use of ab167197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa.

Target

  • Relevance
    MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. Isoform 2 is degraded by the ubiquitin-proteasome pathway.
  • Database links
  • Alternative names
    • FLJ12438 antibody
    • FLJ38609 antibody
    • IGFBP 2 binding protein antibody
    • IGFBP2 binding protein antibody
    • IIP45 antibody
    • Invasion inhibitory protein 45 antibody
    • Migration and invasion inhibitory protein antibody
    • RP5 1077B9.4 antibody
    see all

Images

  • All lanes : Anti-MIIP antibody (ab167197) at 1 µg/ml

    Lane 1 : Lysate of 293T cells transfected with MIIP
    Lane 2 : Lysate of 293T cells (non-transfected)

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

    Predicted band size: 43 kDa

References

ab167197 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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