General notesab94238 is a 293T cell transfected lysate in which Human Human Milk Fat Globule 1 has been transiently over-expressed using a pCMV-Human Milk Fat Globule 1 plasmid. The lysate is provided in 1 x Sample Buffer. Note: For more details about how the transfected lysate was prepared view preparation notes
BackgroundFunction: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.
Medin is the main constituent of aortic medial amyloid.
Tissue specificity: Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
Similarity: Contains 1 EGF-like domain.
Contains 2 F5/8 type C domains.
PTM: Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.