Overview

  • Product nameMilnacipran hydrochloride
  • Description
    Serotonin and norepinephrine reuptake inhibitor
  • Biological descriptionSerotonin and norepinephrine reuptake inhibitor. IC50 values are 100, 203 and >100000 nM for NA, 5-HT and DA, respectively. Centrally active following oral administration. Exhibits antidepressant and antifibromyalgia activity in vivo.
  • Purity> 99%

Properties

    Applications

    Our Abpromise guarantee covers the use of ab120755 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    Milnacipran hydrochloride images

    • ab113202 staining NET1 in PC-12 cells treated with milnacipran hydrochloride (ab120755), by ICC/IF. Decrease of NET1 expression correlates with increased concentration of milnacipran hydrochloride, as described in literature.
      The NGF treated cells were incubated at 37°C for 6 hour in media containing different concentrations of ab120755 (milnacipran hydrochloride ) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab113202 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    References for Milnacipran hydrochloride (ab120755)

    This product has been referenced in:
    • Uchida M  et al. Intranasal administration of milnacipran in rats: evaluation of the transport of drugs to the systemic circulation and central nervous system and the pharmacological effect. Biol Pharm Bull 34:740-7 (2011). Read more (PubMed: 21532166) »
    • Puozzo C  et al. Pharmacology and pharmacokinetics of milnacipran. Int Clin Psychopharmacol 17 Suppl 1:S25-35 (2002). Read more (PubMed: 12369608) »
    • Moret C  et al. Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 24:1211-9 (1985). Read more (PubMed: 3005901) »

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