Overview

  • Product name
    Mitomycin C (MMC)
  • Description
    Anticancer and antibiotic agent
  • Alternative names
    • MMC
  • Biological description

    Anticancer and antibiotic agent. Crosslinks DNA. Inhibits DNA synthesis and nuclear division. Also induces apoptosis.

  • Purity
    > 99%

Properties

Applications

Our Abpromise guarantee covers the use of ab120797 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • Functional assays: Caspase 8 (active) FITC Staining Kit (ab65614)

    Active caspase 8 in control Jurkat cells (10e6/mL) or cells treated for five hours with 10 ug/mL Cyclohexamide (CHX) (ab120093) or four hours with 25 ug/mL Mitomycin C (MitoC) (ab120797). Background signal subtracted, duplicates; +/- SD.

References

This product has been referenced in:
  • Mladenov E  et al. Activation of the S phase DNA damage checkpoint by mitomycin C. J Cell Physiol 211:468-76 (2007). Read more (PubMed: 17167777) »
  • Park IC  et al. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner in human gastric adenocarcinoma cells. Cancer Lett 158:125-32 (2000). Read more (PubMed: 10960761) »
  • Sasaki M  et al. Re-evaluation of tumor-specific cytotoxicity of mitomycin C, bleomycin and peplomycin. Anticancer Res 26:3373-80 (0). Read more (PubMed: 17094455) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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