Overview

  • Product name
    MK 212 hydrochloride
  • Description
    Potent, selective 5-HT2C receptor agonist
  • Biological description
    Potent, selective 5-HT2C receptor agonist (IC50 values are 28 and 420 nM for 5-HT2C and 5-HT2A receptors, respectively). Shows anxiogenic effects and decreases locomotor activity in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    2-Chloro-6-(1-piperazinyl)pyrazine hydrochloride
  • Molecular weight
    235.12
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C8H11ClN4.HCl
  • CAS Number
    61655-58-1
  • PubChem identifier
    198421
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    c1c(nc(cn1)Cl)N2CCNCC2.Cl
  • Source

    Synthetic

References

This product has been referenced in:
  • Kuznetsova EG  et al. Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice. Bull Exp Biol Med 142:594-7 (2006). Read more (PubMed: 17415471) »
  • de Mello Cruz AP  et al. Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology (Berl) 182:345-54 (2005). Read more (PubMed: 16133141) »
  • Hemrick-Luecke SK & Fuller RW Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentrations by quipazine and MK-212. Eur J Pharmacol 311:207-11 (1996). Read more (PubMed: 8891601) »

See 0 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab146439.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up