• Product nameAnti-MKKS antibody
    See all MKKS primary antibodies
  • Description
    Rabbit polyclonal to MKKS
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 407-438 of Human MKKS (NP_740754.1, NP_061336.1).

  • Positive control
    • U251 cell line lysate



Our Abpromise guarantee covers the use of ab123980 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 62 kDa.


  • FunctionProbable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis.
  • Tissue specificityWidely expressed in adult and fetal tissues.
  • Involvement in diseaseDefects in MKKS are the cause of McKusick-Kaufman syndrome (MKKS) [MIM:236700]. MKKS is an autosomal recessive developmental disorder. It is characterized by hydrometrocolpos, postaxial polydactyly and congenital heart defects.
    Defects in MKKS are the cause of Bardet-Biedl syndrome type 6 (BBS6) [MIM:209900]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.
  • Sequence similaritiesBelongs to the TCP-1 chaperonin family.
  • DomainThe substrate-binding apical domain region is sufficient for centrosomal association.
  • Cellular localizationCytoplasm > cytoskeleton > centrosome. Cytoplasm > cytosol. The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the protein is confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found at the intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Bardet Biedl syndrome 6 protein antibody
    • Bardet-Biedl syndrome 6 protein antibody
    • BBS6 antibody
    • HMCS antibody
    • KMS antibody
    • McKusick Kaufman syndrome antibody
    • McKusick Kaufman/Bardet Biedl syndromes putative chaperonin antibody
    • McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin antibody
    • Mkks antibody
    • MKKS_HUMAN antibody
    • MKS antibody
    see all

Anti-MKKS antibody images

  • Anti-MKKS antibody (ab123980) at 1/100 dilution + U251 cell line lysate at 35 µg

    Predicted band size : 62 kDa

References for Anti-MKKS antibody (ab123980)

ab123980 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab123980.
Please use the links above to contact us or submit feedback about this product.