Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-VTKEESEKEQTAVET
    • Amino acids
      195 to 209

Specifications

Our Abpromise guarantee covers the use of ab45735 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • E3 ubiquitin-protein ligase makorin-1
    • FLJ21334
    • HGNC:7112
    • Makorin
    • Makorin ring finger protein 1
    • MKRN 1
    • mkrn1
    • MKRN1_HUMAN
    • OTTHUMP00000212117
    • OTTHUMP00000212118
    • OTTHUMP00000212121
    • OTTHUMP00000212124
    • Ring finger protein 1
    • RING finger protein 61
    • RNF61
    see all
  • Function
    E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
  • Tissue specificity
    Ubiquitous.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 4 C3H1-type zinc fingers.
    Contains 1 RING-type zinc finger.
  • Post-translational
    modifications
    Auto-ubiquitinated; which leads to proteasomal degradation.
  • Information by UniProt

References

ab45735 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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