Biological descriptionPotent and selective myosin light chain kinase inhibitor (MLCK) (Ki = 300 nM). Also inhibits PKA and PKC (Ki values are 21 and 42 μM, respectively). Cell-permeable. Inhibits tumor cell growth.
Chemical nameHexahydro-1-[(5-Iodo-1-naphthaleny)sulfonyl]-1H-1,4-diazepine hydrochloride
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Barkan D et al. Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res68:6241-50 (2008).
Read more (PubMed: 18676848) »
Petrache I et al. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol280:L1168-78 (2001).
Read more (PubMed: 11350795) »
Zhou FQ & Cohan CS Growth cone collapse through coincident loss of actin bundles and leading edge actin without actin depolymerization. J Cell Biol153:1071-84 (2001).
Read more (PubMed: 11381091) »