Anti-MLF1 Interacting Protein/PBIP1 antibody (ab117078)


  • Product nameAnti-MLF1 Interacting Protein/PBIP1 antibody
    See all MLF1 Interacting Protein/PBIP1 primary antibodies
  • Description
    Rabbit polyclonal to MLF1 Interacting Protein/PBIP1
  • Tested applicationsSuitable for: WB, IP, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog, Chimpanzee
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to amino acids surrounding Thr78 of Human MLF1 Interacting Protein/PBIP1. The immunogen peptide is phosphorylated at Thr78.

  • Positive control
    • Human Colon Adenocarcinoma tissue



Our Abpromise guarantee covers the use of ab117078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 48 kDa.
IP Use at an assay dependent concentration.
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.


  • FunctionComponent of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.
  • Tissue specificityExpressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.
  • Post-translational
    Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.
  • Cellular localizationCytoplasm. Nucleus. Chromosome > centromere > kinetochore. Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.
  • Information by UniProt
  • Database links
  • Alternative names
    • CENP U antibody
    • CENP-50 antibody
    • CENP-U antibody
    • CENP50 antibody
    • CENPU antibody
    • CENPU_HUMAN antibody
    • CENPU50 antibody
    • centromere protein of 50 kDa antibody
    • Centromere protein U antibody
    • FLJ23468 antibody
    • HHV8 LNAIP1 antibody
    • ICEN24 antibody
    • Interphase centromere complex protein 24 antibody
    • Kaposi Sarcoma Herpesvirus latent nuclear antigen interacting protein 1 antibody
    • KLIP-1 antibody
    • KLIP1 antibody
    • KSHV latent nuclear antigen interacting protein 1 antibody
    • KSHV latent nuclear antigen-interacting protein 1 antibody
    • KSHV LNAIP1 antibody
    • LNAIP 1 antibody
    • LNAIP-1 antibody
    • MLF1-interacting protein antibody
    • MLF1IP antibody
    • MLF1IP1 antibody
    • PBIP1 antibody
    • Polo-box-interacting protein 1 antibody
    see all

Anti-MLF1 Interacting Protein/PBIP1 antibody images

  • Human Colon Adenocarcinoma (formalin-fixed, paraffin-embedded) stained withab117078 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-MLF1 Interacting Protein/PBIP1 antibody (ab117078)

ab117078 has not yet been referenced specifically in any publications.

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