• Product nameAnti-MLL5 antibody
    See all MLL5 primary antibodies
  • Description
    Rabbit polyclonal to MLL5
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 92-121 of Human MLL5 (NP_891847, Q8IZD2).

  • Positive control
    • HL60 cell line lysates.



Our Abpromise guarantee covers the use of ab123124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 204 kDa.


  • FunctionHistone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.
  • Tissue specificityWidely expressed in both adult and fetal tissues. Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum.
  • Sequence similaritiesBelongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.
    Contains 1 PHD-type zinc finger.
    Contains 1 SET domain.
  • Post-translational
    O-glycosylation at Thr-440 in the SET domain by OGT is essential for the histone methyltransferase and the coactivator activity toward RARA in granulopoiesis. The absence of Thr-440 glycosylation in assays done in vitro may explain why some authors did not detected any histone methyltransferase activity for this protein.
  • Cellular localizationNucleus speckle. Absent from the nucleolus.
  • Information by UniProt
  • Database links
  • Alternative names
    • HDCMC04P antibody
    • Histone lysine N methyltransferase MLL5 antibody
    • Histone-lysine N-methyltransferase MLL5 antibody
    • KMT2E antibody
    • Lysine N methyltransferase 2E antibody
    • Lysine N-methyltransferase 2E antibody
    • MGC70452 antibody
    • Mll5 antibody
    • MLL5_HUMAN antibody
    • Myeloid/lymphoid or mixed lineage leukemia 5 (trithorax homolog, Drosophila) antibody
    • Myeloid/lymphoid or mixed lineage leukemia 5 antibody
    • Myeloid/lymphoid or mixed lineage leukemia protein 5 antibody
    • Myeloid/lymphoid or mixed-lineage leukemia protein 5 antibody
    see all

Anti-MLL5 antibody images

  • Anti-MLL5 antibody (ab123124) at 1/100 dilution + HL60 cell line lysates at 35 µg

    Predicted band size : 204 kDa

References for Anti-MLL5 antibody (ab123124)

ab123124 has not yet been referenced specifically in any publications.

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