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Storage instructions Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
Storage buffer Preservative: 0.09% Sodium Azide
Concentration information loading...
Purity Immunogen affinity purified
Purification notes ab103459 is purified through a protein A column, followed by peptide affinity purification.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Predicted molecular weight: 47 kDa.
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Function Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis.
Tissue specificity Widely expressed. Highest expression is observed in liver and skeletal muscle.
Pathway Cofactor biosynthesis; adenosylcobalamin biosynthesis.
Involvement in disease Defects in MMAA are the cause of methylmalonic aciduria type cblA (MMAA) [MIM:251100]; also known as methylmalonic aciduria type A or vitamin B12-responsive methylmalonicaciduria of cblA complementation type. MMAA is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive.
Sequence similarities Belongs to the ArgK family.
Cellular localization Mitochondrion.
Information by UniProt
Methylmalonic aciduria (cobalamin deficiency) cblA type antibody
Methylmalonic aciduria (cobalamin deficiency) type A antibody
Anti-MMAA antibody images
Western blot - MMAA antibody (ab103459)
Anti-MMAA antibody (ab103459) at 1/100 dilution + Mouse liver tissue lysate at 35 µg Predicted band size : 47 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MMAA antibody (ab103459)
ab103459, at 1/50 dilution, staining MMAA in formalin-fixed, paraffin-embedded human skeletal muscle tissue by Immunohistochemistry using a peroxidase conjugated secondary antibody and DAB staining.
References for Anti-MMAA antibody (ab103459)
has not yet been referenced specifically in any publications.
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