Overview

  • Product nameAnti-MMAA antibody
    See all MMAA primary antibodies
  • Description
    Rabbit polyclonal to MMAA
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 63-92 of Human MMAA.

  • Positive control
    • Mouse liver tissue lysate; human skeletal muscle tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab103459 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 47 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionProbable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis.
  • Tissue specificityWidely expressed. Highest expression is observed in liver and skeletal muscle.
  • PathwayCofactor biosynthesis; adenosylcobalamin biosynthesis.
  • Involvement in diseaseDefects in MMAA are the cause of methylmalonic aciduria type cblA (MMAA) [MIM:251100]; also known as methylmalonic aciduria type A or vitamin B12-responsive methylmalonicaciduria of cblA complementation type. MMAA is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive.
  • Sequence similaritiesBelongs to the ArgK family.
  • Cellular localizationMitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • cblA antibody
    • Methylmalonic aciduria (cobalamin deficiency) cblA type antibody
    • Methylmalonic aciduria (cobalamin deficiency) type A antibody
    • Methylmalonic aciduria type A protein antibody
    • Methylmalonic aciduria type A protein mitochondrial antibody
    • MGC120010 antibody
    • MGC120011 antibody
    • MGC120012 antibody
    • MGC120013 antibody
    • mitochondrial antibody
    • MMAA antibody
    • MMAA_HUMAN antibody
    • OTTHUMP00000220105 antibody
    see all

Anti-MMAA antibody images

  • Anti-MMAA antibody (ab103459) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

    Predicted band size : 47 kDa
  • ab103459, at 1/50 dilution, staining MMAA in formalin-fixed, paraffin-embedded human skeletal muscle tissue by Immunohistochemistry using a peroxidase conjugated secondary antibody and DAB staining.

References for Anti-MMAA antibody (ab103459)

ab103459 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab103459.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"