Overview

  • Product name
  • Description
    Rabbit polyclonal to MMAB
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 19-250 of Human MMAB (UniProt ID: Q96EY8).

  • Positive control
    • HepG2 whole cell lysate; Human hepatoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab154156 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 27 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Tissue specificity
    Expressed in liver and skeletal muscle.
  • Pathway
    Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.
  • Involvement in disease
    Defects in MMAB are the cause of methylmalonic aciduria type cblB (MMAB) [MIM:251110]; also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive.
  • Sequence similarities
    Belongs to the Cob(I)alamin adenosyltransferase family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • aquocob(I)alamin vitamin B12s adenosyltransferase antibody
    • ATP:cob(I)alamin adenosyltransferase antibody
    • ATP:corrinoid adenosyltransferase antibody
    • ATR antibody
    • c-diamide adenosyltransferase antibody
    • cblB antibody
    • Cob antibody
    • Cob(I)alamin adenosyltransferase antibody
    • Cob(I)yrinic acid a antibody
    • cob(I)yrinic acid a c diamide adenosyltransferase mitochondrial antibody
    • Methylmalonic aciduria (cobalamin deficiency) cblB type antibody
    • Methylmalonic aciduria type B protein antibody
    • MGC20496 antibody
    • mitochondrial antibody
    • MMAB antibody
    • MMAB gene antibody
    • MMAB_HUMAN antibody
    • OTTHUMP00000240563 antibody
    • OTTHUMP00000240564 antibody
    see all

Images

  • Anti-MMAB antibody (ab154156) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 27 kDa
  • Immunohistochemical analysis of paraffin-embedded Human hepatoma tissue labeling MMAB with ab154156 at 1/500 dilution.

References

ab154156 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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