Anti-MMP1 antibody [SB12e] (HRP) (ab46667)


  • Product nameAnti-MMP1 antibody [SB12e] (HRP)
    See all MMP1 primary antibodies
  • Description
    Mouse monoclonal [SB12e] to MMP1 (HRP)
  • ConjugationHRP
  • SpecificityAb46667 recognizes MMP1; It does not cross react to MMP2, MMP3 or MMP9.
  • Tested applicationsSuitable for: WB, IHC-Fr, IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant human MMP1.



Our Abpromise guarantee covers the use of ab46667 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 54 kDa.
IHC-Fr 1/20 - 1/40.
IHC-P Use at an assay dependent dilution.
ELISA 1/1000 - 1/4000.


  • FunctionCleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThere are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • 27 kDa interstitial collagenase antibody
    • CLG antibody
    • CLGN antibody
    • collagenase, fibroblast antibody
    • collagenase, interstitial antibody
    • Fibroblast collagenase antibody
    • Interstitial collagenase antibody
    • Matrix metallopeptidase 1 (interstitial collagenase) antibody
    • Matrix metalloprotease 1 antibody
    • Matrix Metalloproteinase 1 antibody
    • Matrix metalloproteinase-1 antibody
    • MMP 1 antibody
    • MMP-1 antibody
    • MMP1 antibody
    • MMP1_HUMAN antibody
    • OTTHUMP00000045866 antibody
    see all

References for Anti-MMP1 antibody [SB12e] (HRP) (ab46667)

ab46667 has not yet been referenced specifically in any publications.

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Thank you for your enquiry. This product is a licensed clone and the owner did not provide that information to us. Please let us know if we can further assist you.

Thank you for your enquiry. I have contacted the originator of the product but unfortunately, epitope mapping has not been done for this product. Therefore, we do not have any information on the epitope sequence. I am sorry I can't be of more as...

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