• Product nameAnti-MMP11 antibody [EP1259Y]
    See all MMP11 primary antibodies
  • Description
    Rabbit monoclonal [EP1259Y] to MMP11
  • Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
    Unsuitable for: Flow Cyt or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to residues near the C-terminus of human MMP11.

  • Positive control
    • MCF-7 cell lysate, human breast carcinoma tissue or MCF7 cells.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.


    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.


Associated products


Our Abpromise guarantee covers the use of ab52904 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100 - 1/250.
WB 1/500. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).
IHC-P Use at an assay dependent concentration.
  • Application notesIs unsuitable for Flow Cyt or IP.
  • Target

    • FunctionMay play an important role in the progression of epithelial malignancies.
    • Tissue specificitySpecifically expressed in stromal cells of breast carcinomas.
    • Sequence similaritiesBelongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • Post-translational
      The precursor is cleaved by a furin endopeptidase.
    • Cellular localizationSecreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • Matrix Metalloproteinase 11 antibody
      • Matrix metalloproteinase-11 antibody
      • MMP-11 antibody
      • Mmp11 antibody
      • MMP11_HUMAN antibody
      • SL 3 antibody
      • SL-3 antibody
      • SL3 antibody
      • ST3 antibody
      • STMY3 antibody
      • Stromelysin 3 antibody
      • Stromelysin III antibody
      • Stromelysin-3 antibody
      see all

    Anti-MMP11 antibody [EP1259Y] images

    • Anti-MMP11 antibody [EP1259Y] (ab52904) at 1/500 dilution + MCF-7 cell lysate at 10 µg

      Goat anti-Rabbit HRP labeled. at 1/2000 dilution

      Predicted band size : 55 kDa
      Observed band size : 55 kDa
    • Ab52904 (1:100) staining human MMP11 in human breast carcinoma tissue by immunohistochemistry using paraffin embedded tissue.
    • Immunofluorescent staining of MCF7 cells using ab52904 (1:100).

    References for Anti-MMP11 antibody [EP1259Y] (ab52904)

    This product has been referenced in:
    • Yonemori M  et al. Dual tumor-suppressors miR-139-5p and miR-139-3p targeting matrix metalloprotease 11 in bladder cancer. Cancer Sci 107:1233-42 (2016). WB ; Human . Read more (PubMed: 27355528) »
    • Roscilli G  et al. Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. J Transl Med 12:54 (2014). IHC-P ; Human . Read more (PubMed: 24564996) »

    See all 3 Publications for this product

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Blocking step BSA as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: 21°C
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citric acid
    Sample Human Tissue sections (Breast carcinoma)
    Specification Breast carcinoma
    Permeabilization No
    Fixative Formaldehyde

    Mr. Carl Hobbs

    Verified customer

    Submitted Jun 12 2013

    Thank you for your telephone call earlier this afternoon. I am very pleased to hear you would like to accept our offer and test ab52904 in IHC-Fr.

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