Overview

  • Product nameAnti-MMP11 antibody [SL3.05]
    See all MMP11 primary antibodies
  • Description
    Mouse monoclonal [SL3.05] to MMP11
  • Tested applicationsSuitable for: WB, IP, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant protein corresponding to active form of human MMP11.

  • Positive control
    • Small intestine tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab85648 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 55 kDa.
IP Use at an assay dependent concentration.
IHC-P 1/200.

Target

  • FunctionMay play an important role in the progression of epithelial malignancies.
  • Tissue specificitySpecifically expressed in stromal cells of breast carcinomas.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Matrix Metalloproteinase 11 antibody
    • Matrix metalloproteinase-11 antibody
    • MMP-11 antibody
    • Mmp11 antibody
    • MMP11_HUMAN antibody
    • SL 3 antibody
    • SL-3 antibody
    • SL3 antibody
    • ST3 antibody
    • STMY3 antibody
    • Stromelysin 3 antibody
    • Stromelysin III antibody
    • Stromelysin-3 antibody
    see all

Anti-MMP11 antibody [SL3.05] images

  • ab85648, at a 1/200 dilution, staining MMP11 in formalin fixed, paraffin embedded human small intestine tissue by Immunohistochemistry.

References for Anti-MMP11 antibody [SL3.05] (ab85648)

This product has been referenced in:
  • Meyer BS & Rademann J Extra- and Intracellular Imaging of Human Matrix Metalloprotease 11 (hMMP-11) with a Cell-penetrating FRET Substrate. J Biol Chem 287:37857-67 (2012). WB . Read more (PubMed: 22927434) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"