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Function
Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
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Tissue specificity
Seems to be specific to breast carcinomas.
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Involvement in disease
Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:602111]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.
Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:602111]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.
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Sequence similarities
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.
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Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
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Cellular localization
Secreted > extracellular space > extracellular matrix.
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Information by UniProt
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Database links
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Alternative names
- CLG 3 antibody
- CLG3 antibody
- Collagenase 3 antibody
- Collagenase3 antibody
- MANDP1 antibody
- Matrix metallopeptidase 13 (collagenase 3) antibody
- Matrix Metalloproteinase 13 antibody
- Matrix metalloproteinase-13 antibody
- MMP 13 antibody
- MMP-13 antibody
- Mmp13 antibody
- MMP13_HUMAN antibody
see all