Anti-MMP14 antibody [EP1264Y] (ab51074)

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ab51074 has been referenced in 63 publications.

  • Li T  et al. The interactome and spatial redistribution feature of Ca2+receptor protein calmodulin reveals a novel role in invadopodia-mediated invasion. Cell Death Dis 9:292 (2018). PubMed: 29463791
  • Di D  et al. Association of BCSC-1 and MMP-14 with human breast cancer. Oncol Lett 15:5020-5026 (2018). PubMed: 29552138
  • Braun A  et al. A cell surface display fluorescent biosensor for measuring MMP14 activity in real-time. Sci Rep 8:5916 (2018). PubMed: 29651043
  • Pekkonen P  et al. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and ß1-integrin activation. Elife 7:N/A (2018). ICC/IF ; Human . PubMed: 29712618
  • Landolt L  et al. Clear Cell Renal Cell Carcinoma is linked to Epithelial-to-Mesenchymal Transition and to Fibrosis. Physiol Rep 5:N/A (2017). IHC . PubMed: 28596300
  • Cunha C  et al. Joint analysis of IVD herniation and degeneration by rat caudal needle puncture model. J Orthop Res 35:258-268 (2017). IHC ; Rat . PubMed: 26610284
  • Peláez R  et al. ß3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells. PLoS One 12:e0181579 (2017). PubMed: 28767724
  • Dourado KMC  et al. Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models. Blood 129:2526-2536 (2017). PubMed: 28351936
  • Swayampakula M  et al. The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. Oncogene 36:6244-6261 (2017). ICC/IF ; Human . PubMed: 28692057
  • Meehan J  et al. Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells. Oncotarget 8:42857-42875 (2017). PubMed: 28476026
  • Ding P  et al. CD147 functions as the signaling receptor for extracellular divalent copper in hepatocellular carcinoma cells. Oncotarget 8:51151-51163 (2017). PubMed: 28881637
  • Hebbrecht T  et al. VCA nanobodies target N-WASp to reduce invadopodium formation and functioning. PLoS One 12:e0185076 (2017). PubMed: 28938008
  • Bendris N  et al. Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells. J Cell Sci 129:2804-16 (2016). PubMed: 27278018
  • Petropoulos C  et al. Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes. J Cell Biol 213:585-99 (2016). PubMed: 27269065
  • Norden PR  et al. Cdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and Cytoskeletal Polarization: Novel Stimulatory Roles for GTPase Effectors, the Small GTPases, Rac2 and Rap1b, and Inhibitory Influence of Arhgap31 and Rasa1. PLoS One 11:e0147758 (2016). PubMed: 26812085
  • Bogachek MV  et al. Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas. Stem Cell Reports 7:1140-1151 (2016). PubMed: 27916539
  • Zhao W  et al. Effect of TGF-ß1 on the Migration and Recruitment of Mesenchymal Stem Cells after Vascular Balloon Injury: Involvement of Matrix Metalloproteinase-14. Sci Rep 6:21176 (2016). WB, IHC-P ; Rat . PubMed: 26880204
  • Du HT & Liu P Matrix metalloproteinase 14 participates in corneal lymphangiogenesis through the VEGF-C/VEGFR-3 signaling pathway. Exp Ther Med 12:2120-2128 (2016). WB ; Mouse . PubMed: 27698700
  • Piccinini AM  et al. Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages. Sci Signal 9:ra86 (2016). ICC/IF . PubMed: 27577261
  • Daubon T  et al. VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells. J Cell Sci 129:2586-98 (2016). WB ; Human . PubMed: 27231093
  • Wong HL  et al. MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis. Nat Commun 7:10824 (2016). PubMed: 26926389
  • Cepeda MA  et al. Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells. Mol Cancer 15:65 (2016). WB ; Human . PubMed: 27756325
  • Gallardo-Vara E  et al. Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury. Angiogenesis 19:155-71 (2016). IHC, Flow Cyt . PubMed: 26850053
  • Maacha S  et al. Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14). Invest Ophthalmol Vis Sci 57:1982-90 (2016). PubMed: 27096756
  • Rafii S  et al. Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration. Nat Cell Biol 17:123-136 (2015). PubMed: 25621952
  • Bais MV  et al. Orthotopic non-metastatic and metastatic oral cancer mouse models. Oral Oncol 51:476-82 (2015). PubMed: 25682387
  • Ding BS  et al. Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. J Cell Sci 128:2983-8 (2015). WB ; Human . PubMed: 26116571
  • Ponceau A  et al. aII-spectrin regulates invadosome stability and extracellular matrix degradation. PLoS One 10:e0120781 (2015). PubMed: 25830635
  • El Khassawna T  et al. Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats. Histochem Cell Biol 144:491-507 (2015). PubMed: 26210855
  • Kotula E  et al. DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion. Cell Cycle 14:1961-72 (2015). WB . PubMed: 26017556
  • Ager EI  et al. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. J Natl Cancer Inst 107:N/A (2015). PubMed: 25710962
  • Vincent ZL  et al. Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta. J Inflamm Res 8:193-200 (2015). WB . PubMed: 26491367
  • Shitomi Y  et al. ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1). Mol Biol Cell 26:659-73 (2015). PubMed: 25540428
  • Lu ZX  et al. Cardioprotective activity of placental growth factor in a rat model of acute myocardial infarction: nanoparticle-based delivery versus direct myocardial injection. BMC Cardiovasc Disord 14:53 (2014). WB, IHC . PubMed: 24742302
  • Hayes EM  et al. Classical and Alternative Activation and Metalloproteinase Expression Occurs in Foam Cell Macrophages in Male and Female ApoE Null Mice in the Absence of T and B Lymphocytes. Front Immunol 5:537 (2014). IHC-P ; Mouse . PubMed: 25389425
  • Cyr AR  et al. TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis. Oncogene N/A:N/A (2014). Human . PubMed: 24469049
  • Welch-Reardon KM  et al. Angiogenic sprouting is regulated by endothelial cell expression of Slug. J Cell Sci 127:2017-28 (2014). PubMed: 24554431
  • Hong IK  et al. The Tetraspanin CD81 Protein Increases Melanoma Cell Motility by Up-regulating Metalloproteinase MT1-MMP Expression through the Pro-oncogenic Akt-dependent Sp1 Activation Signaling Pathways. J Biol Chem 289:15691-15704 (2014). Human . PubMed: 24733393
  • Appel S  et al. CNN3 regulates trophoblast invasion and is upregulated by hypoxia in BeWo cells. PLoS One 9:e103216 (2014). WB . PubMed: 25050546
  • von Nandelstadh P  et al. Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton. Mol Biol Cell 25:2556-70 (2014). Mouse . PubMed: 24989798
  • Küttner V  et al. Global remodelling of cellular microenvironment due to loss of collagen VII. Mol Syst Biol 9:657 (2013). PubMed: 23591773
  • Kumar S  et al. Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-ß signaling. Oncogene N/A:N/A (2013). PubMed: 24077288
  • Lee JH  et al. N-Acetylglucosaminyltransferase V triggers overexpression of MT1-MMP and reinforces the invasive/metastatic potential of cancer cells. Biochem Biophys Res Commun 431:658-63 (2013). PubMed: 23357422
  • Mori H  et al. Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin ß1. Development 140:343-52 (2013). WB . PubMed: 23250208
  • Havre PA  et al. CD26 Expression on T-Anaplastic Large Cell Lymphoma (ALCL) Line Karpas 299 is associated with increased expression of Versican and MT1-MMP and enhanced adhesion. BMC Cancer 13:517 (2013). Flow Cyt ; Human . PubMed: 24180670
  • Woskowicz AM  et al. MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion. J Biol Chem 288:35126-37 (2013). WB . PubMed: 24165131
  • Xiao Q  et al. Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions. Circ Res 112:35-47 (2013). PubMed: 23071158
  • Xiao W  et al. Knockdown of FAK inhibits the invasion and metastasis of Tca-8113 cells in vitro. Mol Med Rep 8:703-7 (2013). PubMed: 23807215
  • Urso ML  et al. Adenosine A3 receptor stimulation reduces muscle injury following physical trauma and is associated with alterations in the MMP/TIMP response. J Appl Physiol 112:658-70 (2012). WB ; Mouse . PubMed: 22114177
  • Ming XF  et al. Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis. J Am Heart Assoc 1:e000992 (2012). PubMed: 23130157
  • Jin G  et al. MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. EMBO J 30:2281-93 (2011). PubMed: 21572390
  • Wittschieber D  et al. Decreased RECK and Increased EMMPRIN expression in urothelial carcinoma of the bladder are associated with tumor aggressiveness. Pathobiology 78:123-31 (2011). PubMed: 21613799
  • Bialek J  et al. Relaxin enhances the collagenolytic activity and in vitro invasiveness by upregulating matrix metalloproteinases in human thyroid carcinoma cells. Mol Cancer Res 9:673-87 (2011). ICC/IF ; Human . PubMed: 21493587
  • Ferraro GB  et al. Membrane-type Matrix Metalloproteinase-3 Regulates Neuronal Responsiveness to Myelin through Nogo-66 Receptor 1 Cleavage. J Biol Chem 286:31418-24 (2011). PubMed: 21768085
  • Bernert B  et al. Hyaluronan Synthase 2 (HAS2) Promotes Breast Cancer Cell Invasion by Suppression of Tissue Metalloproteinase Inhibitor 1 (TIMP-1). J Biol Chem 286:42349-59 (2011). WB . PubMed: 22016393
  • Rezvani HR  et al. Loss of epidermal hypoxia-inducible factor-1a accelerates epidermal aging and affects re-epithelialization in human and mouse. J Cell Sci 124:4172-83 (2011). WB ; Human . PubMed: 22193962
  • Triantafyllopoulou A  et al. Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc Natl Acad Sci U S A 107:3012-7 (2010). WB ; Mouse . PubMed: 20133703
  • Agrawal V  et al. Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci U S A 107:3351-5 (2010). IHC-P ; Mouse . PubMed: 19966310
  • Saha A  et al. Lack of an endogenous anti-inflammatory protein in mice enhances colonization of B16F10 melanoma cells in the lungs. J Biol Chem 285:10822-31 (2010). WB ; Mouse . PubMed: 20118237
  • Hawinkels LJ  et al. Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer Res 70:4141-50 (2010). WB, IHC-P ; Human . PubMed: 20424116
  • Miller JP  et al. Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease. Neuron 67:199-212 (2010). WB ; Human . PubMed: 20670829
  • Barnes BR  et al. Alterations in mRNA and protein levels of metalloproteinases-2, -9, and -14 and tissue inhibitor of metalloproteinase-2 responses to traumatic skeletal muscle injury. Am J Physiol Cell Physiol 297:C1501-8 (2009). PubMed: 19794148
  • Fromigué O  et al. Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. J Biol Chem 283:30549-56 (2008). ICC/IF ; Human . PubMed: 18757369


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