Overview

  • Product nameAnti-MMP15 antibody
    See all MMP15 primary antibodies
  • Description
    Rabbit polyclonal to MMP15
  • SpecificityThis antibody detects endogenous levels of total MMP15 protein.
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic MMP15 peptide (Human)

  • Positive control
    • Extracts from MDA-MB-435 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab53770 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/10000.
WB 1/500 - 1/1000. Detects a band of approximately 76 kDa (predicted molecular weight: 76 kDa).

Target

  • FunctionEndopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
  • Tissue specificityAppeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI503551 antibody
    • Matrix metallopeptidase 15 membrane inserted antibody
    • Matrix metalloproteinase 15 antibody
    • Matrix metalloproteinase-15 antibody
    • Membrane type 2 matrix metalloproteinase antibody
    • Membrane type matrix metalloproteinase 2 antibody
    • Membrane-type matrix metalloproteinase 2 antibody
    • Membrane-type-2 matrix metalloproteinase antibody
    • MMP 15 antibody
    • MMP-15 antibody
    • MMP15 antibody
    • MMP15_HUMAN antibody
    • MT MMP 2 antibody
    • MT-MMP 2 antibody
    • MT2 MMP antibody
    • MT2-MMP antibody
    • MT2MMP antibody
    • MTMMP 2 antibody
    • MTMMP2 antibody
    • SMCP 2 antibody
    • SMCP-2 antibody
    • SMCP2 antibody
    see all

Anti-MMP15 antibody images

  • All lanes : Anti-MMP15 antibody (ab53770) at 1/500 dilution

    Lane 1 : Extracts from MDA-MB-435 cells
    Lane 2 : Extracts from MDA-MB-435 cells, plus peptide


    Predicted band size : 76 kDa
    Observed band size : 76 kDa

References for Anti-MMP15 antibody (ab53770)

This product has been referenced in:
  • Silva EJ  et al. S100A8/A9 regulates MMP-2 expression and invasion and migration by carcinoma cells. Int J Biochem Cell Biol 55:279-87 (2014). WB ; Human . Read more (PubMed: 25236491) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"