Anti-MMP15 antibody [MM0028-5D11] (ab56308)

Overview

  • Product nameAnti-MMP15 antibody [MM0028-5D11]
    See all MMP15 primary antibodies
  • Description
    Mouse monoclonal [MM0028-5D11] to MMP15
  • Specificityab56308 recognizes human MMP15 in western blot without cross reactivity with human MMP14/16. Reactivity with MMP15 in other species has not been tested.
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human recombinant MMP15

Properties

Applications

Our Abpromise guarantee covers the use of ab56308 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB Use at an assay dependent concentration. Predicted molecular weight: 76 kDa.

Target

  • FunctionEndopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
  • Tissue specificityAppeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI503551 antibody
    • Matrix metallopeptidase 15 membrane inserted antibody
    • Matrix metalloproteinase 15 antibody
    • Matrix metalloproteinase-15 antibody
    • Membrane type 2 matrix metalloproteinase antibody
    • Membrane type matrix metalloproteinase 2 antibody
    • Membrane-type matrix metalloproteinase 2 antibody
    • Membrane-type-2 matrix metalloproteinase antibody
    • MMP 15 antibody
    • MMP-15 antibody
    • MMP15 antibody
    • MMP15_HUMAN antibody
    • MT MMP 2 antibody
    • MT-MMP 2 antibody
    • MT2 MMP antibody
    • MT2-MMP antibody
    • MT2MMP antibody
    • MTMMP 2 antibody
    • MTMMP2 antibody
    • SMCP 2 antibody
    • SMCP-2 antibody
    • SMCP2 antibody
    see all

Anti-MMP15 antibody [MM0028-5D11] images

  • ab56308 at 1/200 dilution, staining MMP15 in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

References for Anti-MMP15 antibody [MM0028-5D11] (ab56308)

ab56308 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. We do not have set expiration dates for our products. Most antibodies are stable and can last for anywhere from a few months to several years if stored properly, so we strongly recommend that you follow the storage instr...

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Thank you for contacting us. I was informed that it was tested to pick up the extracellular domain of the recombinant protein. Unfortunately, we do not have the detailed epitope information available. We aim to provide as much information...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"