Overview

  • Product nameAnti-MMP16 antibody
    See all MMP16 primary antibodies
  • Description
    Rabbit polyclonal to MMP16
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthesized peptide derived from human MMP16.

  • Positive control
    • HepG2 cell extracts; Human brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab53145 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 57 kDa.
ELISA 1/10000.

Target

  • FunctionEndopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
  • Tissue specificityExpressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • Developmental stageExpressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationCell membrane. Localized at the cell surface of melanoma cells and Secreted > extracellular space > extracellular matrix. Cell surface. Localized at the cell surface of melanoma cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • C8orf57 antibody
    • DKFZp761D112 antibody
    • Matrix metalloproteinase 16 antibody
    • Matrix metalloproteinase-16 antibody
    • Membrane type 3 matrix metalloproteinase antibody
    • Membrane type matrix metalloproteinase 3 antibody
    • Membrane-type matrix metalloproteinase 3 antibody
    • Membrane-type-3 matrix metalloproteinase antibody
    • MMP 16 antibody
    • MMP-16 antibody
    • MMP-X2 antibody
    • MMP16 antibody
    • MMP16_HUMAN antibody
    • MT-MMP 3 antibody
    • MT-MMP2 antibody
    • MT-MMP3 antibody
    • MT3-MMP antibody
    • MT3MMP antibody
    • MTMMP2 antibody
    • MTMMP3 antibody
    • Putative transmembrane protein C8orf57 antibody
    see all

Anti-MMP16 antibody images

  • All lanes : Anti-MMP16 antibody (ab53145) at 1/500 dilution

    Lane 1 : HepG2 cell extract
    Lane 2 : HepG2 cell extract with immunizing peptide


    Predicted band size : 57 kDa

References for Anti-MMP16 antibody (ab53145)

This product has been referenced in:
  • Hadchouel A  et al. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. PLoS ONE 3:e3188 (2008). WB ; Human . Read more (PubMed: 18784838) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"