Overview

  • Product nameAnti-MMP17 antibody
    See all MMP17 primary antibodies
  • Description
    Rabbit polyclonal to MMP17
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit
  • Immunogen

    Synthetic peptide:

    KDNNVEEGYPRPVSD

    conjugated to KLH, corresponding to amino acids 409-423 of Human MMP17

  • Positive control
    • Human Small Intestine tissue

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab115761 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionEndopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
  • Tissue specificityExpressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationCell membrane. Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Matrix metalloproteinase 17 antibody
    • Matrix metalloproteinase 17 membrane inserted antibody
    • Matrix metalloproteinase-17 antibody
    • Membrane type 4 matrix metalloproteinase antibody
    • Membrane type matrix metalloproteinase 4 antibody
    • Membrane-type matrix metalloproteinase 4 antibody
    • Membrane-type-4 matrix metalloproteinase antibody
    • MMP 17 antibody
    • MMP-17 antibody
    • Mmp17 antibody
    • MMP17_HUMAN antibody
    • MT MMP 4 antibody
    • MT MMP4 antibody
    • MT-MMP 4 antibody
    • MT4 MMP antibody
    • MT4-MMP antibody
    • MT4MMP antibody
    • MTMMP 4 antibody
    • MTMMP4 antibody
    see all

Anti-MMP17 antibody images

  • Human Small Intestine (formalin-fixed, paraffin-embedded) stained with ab115761 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-MMP17 antibody (ab115761)

ab115761 has not yet been referenced specifically in any publications.

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