Overview

  • Product name
    Anti-MMP19 antibody, prediluted
    See all MMP19 primary antibodies
  • Description
    Rabbit polyclonal to MMP19, prediluted
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (N terminal).

  • Positive control
    • Placenta.

Properties

Applications

Our Abpromise guarantee covers the use of ab15477 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Ready to use for 10 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
    • Tissue specificity
      Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.
    • Involvement in disease
      May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.
    • Sequence similarities
      Belongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • Domain
      The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • Post-translational
      modifications
      Activated by autolytic cleavage after Lys-97.
    • Cellular localization
      Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • Matrix metalloproteinase 18 antibody
      • Matrix metalloproteinase 19 antibody
      • Matrix metalloproteinase RASI antibody
      • Matrix metalloproteinase-18 antibody
      • Matrix metalloproteinase-19 antibody
      • MMP 18 antibody
      • MMP 19 antibody
      • MMP-18 antibody
      • MMP-19 antibody
      • MMP18 antibody
      • MMP19 antibody
      • MMP19_HUMAN antibody
      • RASI 1 antibody
      • RASI antibody
      • RASI1 antibody
      see all

    Images

    • ab15477 staining MMP19 in human placenta by Immunohistochemistry (FFPE-sections).

    References

    This product has been referenced in:
    • Ishikawa A  et al. Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia. Neurosci Res 59:406-12 (2007). IHC-P ; Human . Read more (PubMed: 17889387) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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