Overview

  • Product name
  • Description
    Rabbit polyclonal to MMP22
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 324-373 (KILHKKGKVY WYKDQEPLEF SYPGYLALGE AHLSIIANAV NEGTYTCVVR) of Human MMP22 (NP_008914).

  • Positive control
    • Human fetal liver lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab87066 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Protease. May regulate the surface expression of some potassum channels by retaining them in the endoplasmic reticulum.
  • Tissue specificity
    Predominantly expressed in ovary, testis and prostate.
  • Sequence similarities
    Belongs to the peptidase M10A family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Domain
    The toxin-like domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4.
  • Post-translational
    modifications
    N-glycosylated.
    Proteolytic cleavage might yield an active form.
  • Cellular localization
    Endoplasmic reticulum membrane. Membrane. A secreted form produced by proteolytic cleavage may also exist.
  • Information by UniProt
  • Database links
  • Alternative names
    • Femalysin antibody
    • Matrix metallopeptidase 21 antibody
    • matrix metallopeptidase 23B antibody
    • matrix metalloproteinase 22 antibody
    • matrix metalloproteinase 22, formerly antibody
    • Matrix metalloproteinase 23, soluble form antibody
    • Matrix metalloproteinase 23B antibody
    • matrix metalloproteinase in the female reproductive tract antibody
    • Matrix metalloproteinase-21 antibody
    • Matrix metalloproteinase-22 antibody
    • Matrix metalloproteinase-23 antibody
    • MIFR 1 antibody
    • MIFR antibody
    • MIFR-1 antibody
    • MMP 21 antibody
    • MMP 22 antibody
    • MMP 23 antibody
    • MMP-21 antibody
    • MMP-22 antibody
    • MMP-23 antibody
    • MMP21 antibody
    • MMP22 antibody
    • MMP22, formerly antibody
    • MMP23 antibody
    • MMP23_HUMAN antibody
    • MMP23A antibody
    • MMP23B antibody
    • soluble form antibody
    see all

Images

  • Anti-MMP22 antibody (ab87066) at 1 µg/ml (5% skim milk / PBS buffer ) + Human fetal liver lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 36 kDa
    Observed band size : 36 kDa

References

ab87066 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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