Overview

  • Product name
    Anti-MMP25 antibody - C-terminal
    See all MMP25 primary antibodies
  • Description
    Rabbit polyclonal to MMP25 - C-terminal
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide from the C terminal region of human MMP25 conjugated to KLH

  • Positive control
    • Mouse liver tissue and HL60 cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab70881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 63 kDa (predicted molecular weight: 63 kDa).

Target

  • Function
    May activate progelatinase A.
  • Tissue specificity
    Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.
  • Sequence similarities
    Belongs to the peptidase M10A family.
    Contains 4 hemopexin repeats.
  • Domain
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localization
    Cell membrane. Secreted, extracellular space, extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Leukolysin antibody
    • matrix metallopeptidase 25 antibody
    • matrix metallopeptidase like 1 antibody
    • matrix metalloproteinase 20 antibody
    • Matrix Metalloproteinase 25 antibody
    • Matrix metalloproteinase 25 precursor antibody
    • Matrix metalloproteinase-25 antibody
    • Membrane type 6 Matrix Metalloproteinase antibody
    • Membrane type Matrix Metalloproteinase 6 antibody
    • Membrane-type matrix metalloproteinase 6 antibody
    • Membrane-type-6 matrix metalloproteinase antibody
    • MMP 25 antibody
    • MMP-25 antibody
    • MMP20 antibody
    • MMP20A antibody
    • MMP25 antibody
    • MMP25_HUMAN antibody
    • MMPL1 antibody
    • MT-MMP 6 antibody
    • MT6-MMP antibody
    • MT6MMP antibody
    • MTMMP6 antibody
    see all

Images

  • All lanes : Anti-MMP25 antibody - C-terminal (ab70881) at 1/100 dilution

    Lane 1 : Mouse liver tissue lysate
    Lane 2 : HL60 cell lysate

    Lysates/proteins at 12.5 µg per lane.


    Predicted band size : 63 kDa
    Observed band size : 63 kDa

References

ab70881 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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