Overview

  • Product name
    Anti-MMP25 antibody [MM0029-2B5]
    See all MMP25 primary antibodies
  • Description
    Mouse monoclonal [MM0029-2B5] to MMP25
  • Specificity
    ab56309 recognizes MMP25 in western blot.
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Purified Human recombinant MMP25

Properties

Applications

Our Abpromise guarantee covers the use of ab56309 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/500.
WB Use at an assay dependent concentration. Predicted molecular weight: 63 kDa.

Target

  • Function
    May activate progelatinase A.
  • Tissue specificity
    Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.
  • Sequence similarities
    Belongs to the peptidase M10A family.
    Contains 4 hemopexin repeats.
  • Domain
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localization
    Cell membrane. Secreted, extracellular space, extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Leukolysin antibody
    • matrix metallopeptidase 25 antibody
    • matrix metallopeptidase like 1 antibody
    • matrix metalloproteinase 20 antibody
    • Matrix Metalloproteinase 25 antibody
    • Matrix metalloproteinase 25 precursor antibody
    • Matrix metalloproteinase-25 antibody
    • Membrane type 6 Matrix Metalloproteinase antibody
    • Membrane type Matrix Metalloproteinase 6 antibody
    • Membrane-type matrix metalloproteinase 6 antibody
    • Membrane-type-6 matrix metalloproteinase antibody
    • MMP 25 antibody
    • MMP-25 antibody
    • MMP20 antibody
    • MMP20A antibody
    • MMP25 antibody
    • MMP25_HUMAN antibody
    • MMPL1 antibody
    • MT-MMP 6 antibody
    • MT6-MMP antibody
    • MT6MMP antibody
    • MTMMP6 antibody
    see all

Images

  • ab56309 at 1/500 dilution, staining MMP25 in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

References

ab56309 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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