Overview

  • Product nameAnti-MMP28 antibody
    See all MMP28 primary antibodies
  • Description
    Mouse monoclonal to MMP28
  • Tested applicationsSuitable for: WB, Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: LARGGLQVEP YYPRSLQDWG GIPEEVSGAL PRPDGSIIFF RDDRYWRLDQ AKLQATTSGR WATELPWMGC WHANSGSALF , corresponding to amino acids 441-521 of Human MMP28

Properties

Applications

Our Abpromise guarantee covers the use of ab57724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
Sandwich ELISA
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCan degrade casein. Could play a role in tissues homeostasis and repair.
    • Tissue specificityExpressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytesis. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin.
    • Sequence similaritiesBelongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • Post-translational
      modifications
      The precursor is cleaved by a furin endopeptidase.
    • Cellular localizationSecreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • Epilysin antibody
      • Matrix metalloproteinase 28 antibody
      • Matrix metalloproteinase-28 antibody
      • MM 28 antibody
      • MM28 antibody
      • MMP 25 antibody
      • MMP 28 antibody
      • MMP-28 antibody
      • MMP25 antibody
      • MMP28 antibody
      • MMP28_HUMAN antibody
      see all

    Anti-MMP28 antibody images

    Protocols

    References for Anti-MMP28 antibody (ab57724)

    This product has been referenced in:
    • Slany A  et al. Cell characterization by proteome profiling applied to primary hepatocytes and hepatocyte cell lines Hep-G2 and Hep-3B. J Proteome Res 9:6-21 (2010). WB ; Human . Read more (PubMed: 19678649) »

    See 1 Publication for this product

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"