Overview

  • Product nameMMPIP
  • Description
    mGlu7 allosteric antagonist
  • Biological descriptionPotent, selective allosteric antagonist at mGlu7 receptors. Inhibits agonist-induced intracellular calcium mobilisation and cAMP accumulation (IC50 values are 26 and 610 nM). Also displays intrinsic activity; increasing forskolin-induced cAMP accumulation in the absence of an agonist. Exhibits no significant activity at mGluR1, mGluR2, mGluR3, mGluR4, mGluR5, and mGluR8. Also available in Kit: mGlu antagonists (ab120322)
  • Purity> 98%

Properties

    References for MMPIP (ab120245)

    This product has been referenced in:
    • Niswender CM  et al. Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7. Mol Pharmacol 77:459-68 (2010). Read more (PubMed: 20026717) »
    • Li X  et al. Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism. Neuropsychopharmacology 34:1783-96 (2009). Read more (PubMed: 19158667) »
    • Suzuki G  et al. In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J Pharmacol Exp Ther 323:147-56 (2007). Read more (PubMed: 17609420) »

    See all 2 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120245.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"