Overview

  • Product name
  • Description
    Mouse monoclonal to MNDA
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cynomolgus monkey
  • Immunogen

    Synthetic peptide, corresponding to amino acids 311-408 of Human MNDA (NP_002423) with a proprietary tag.

  • Positive control
    • Human kidney tissue
  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

Properties

Applications

Our Abpromise guarantee covers the use of ab118371 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 µg/ml. Antigen retrieval is not essential but may optimise staining. Place sample in 1X citrate buffer (pH 6.0) in pressure cooker under 125oC for 4min and under 90oC for 45min.

Target

  • Function
    May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
  • Tissue specificity
    Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.
  • Sequence similarities
    Contains 1 DAPIN domain.
    Contains 1 HIN-200 domain.
  • Domain
    Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.
  • Cellular localization
    Nucleus. Cytoplasm. Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.
  • Information by UniProt
  • Database links
  • Alternative names
    • MNDA antibody
    • MNDA_HUMAN antibody
    • Myeloid cell nuclear differentiation antigen antibody
    • OTTHUMP00000024384 antibody
    • PYHIN3 antibody
    see all

Anti-MNDA antibody images

  • Formalin-fixed, paraffin-embedded Human kidney tissue labelled with ab118371 at 3 µg/ml

References for Anti-MNDA antibody (ab118371)

ab118371 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab118371.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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