Overview

  • Product name
  • Description
    Rabbit polyclonal to MOCS1
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: LVPAKFEFIV RRKGFHKVME GIHKAIELGY NPVKVNCVVM RGLNEDELLD FAALTEGLPL DVRFIEYMPF DGNKWNFKKM VSYK, corresponding to amino acids of Human MOCS1 (Q9NZB8).

  • Positive control
    • Human stomach tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab126560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration.
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of a guanosine derivative to precursor Z during molybdenum cofactor biosynthesis.
  • Tissue specificity
    Isoform MOCS1A and isoform 2 are widely expressed.
  • Pathway
    Cofactor biosynthesis; molybdopterin biosynthesis.
  • Involvement in disease
    Defects in MOCS1 are the cause of molybdenum cofactor deficiency type A (MOCOD type A) [MIM:252150]; an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.
  • Sequence similarities
    In the C-terminal section; belongs to the moaC family.
    In the N-terminal section; belongs to the moaA/nifB/pqqE family.
  • Post-translational
    modifications
    Isoform MOCS1A, isoform 2 and isoform 3 are probably thiocarboxylated at their C-terminus. Thiocarboxylation probably plays a central role in molybdenum cofactor biosynthesis, since mutagenesis of the last 2 Gly residues of isoform MOCS1A abolishes the catalytic activity of the enzyme. Thiocarboxylation is absent in isoform MOCS1B, which lacks the C-terminal Gly residue.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cell migration-inducing gene 11 protein antibody
    • MIG11 antibody
    • Migration inducing gene 11 protein antibody
    • MOCOD antibody
    • MOCODA antibody
    • Mocs1 antibody
    • MOCS1_HUMAN antibody
    • Molybdenum cofactor biosynthesis protein 1 antibody
    • Molybdenum cofactor biosynthesis protein A antibody
    • Molybdenum cofactor biosynthesis protein C antibody
    • Molybdenum cofactor synthesis 1 antibody
    • Molybdenum cofactor synthesis-step 1 protein A-B antibody
    see all

Images

  • Lane 1: Marker [kDa] 250; 130; 95; 72; 55; 36; 28; 17; 10
    Lane 2: RT-4
    Lane 3: U-251 MG
    Lane 4: Human Plasma
    Lane 5: Liver
    Lane 6: Tonsil
  • ab126560 at 1/50 dilution, staining MOCS1 in Formalin fixed Paraffin-embedded Human stomach tissue by Immunohistochemistry.

References

ab126560 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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