Biological descriptionNa+ ionophore. Forms lipophilic complexes with monovalent cations to induce Na+ influx and H+/K+ efflux. Increases intracellular Ca2+ levels. Exhibits diverse biological actions; displays antibacterial properties and modulates ion gradients and intracellular pH. Apoptosis inducer.
Chemical name4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]- 3-methyloxolan-2-yl]oxolan-2-yl]- 9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid sodium salt
Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Ketola K et al. Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells. Mol Cancer Ther9:3175-85 (2010).
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Mollenhauer HH et al. Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim Biophys Acta1031:225-46 (1990).
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Singh M et al. Effect of monensin, a Na+-specific carboxylic ionophore on the oxidative defense system in rat testis. Pharmacol Rep59:456-61 (0).
Read more (PubMed: 17901575) »