Monoamine Oxidase A peptide (141-154) (ab45814)

Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      DAPWEAQHADKWDK
    • Amino acids
      141 to 154

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Monoamine Oxidase A antibody (ab40835)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

General Info

  • Alternative names
    • Amine oxidase [flavin containing] A
    • Amine oxidase [flavin-containing] A
    • AOFA
    • AOFA_HUMAN
    • EC 1.4.3.4
    • MAO A
    • MAO-A
    • maoA
    • Monoamine oxidase A
    • Monoamine oxidase type A
    see all
  • Function
    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
  • Tissue specificity
    Heart, liver, duodenum, blood vessels and kidney.
  • Involvement in disease
    Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.
  • Sequence similarities
    Belongs to the flavin monoamine oxidase family.
  • Cellular localization
    Mitochondrion outer membrane.
  • Information by UniProt

Images

  • All lanes : Monoamine Oxidase A peptide (141-154) (ab45814) at 0.3 µg/ml

    Lane 1 : Human Heart Lysate
    Lane 2 : Human Heart Lysate with Immunising peptide

    Lysates/proteins at 35 µg per lane.

    Developed using the ECL technique

    Observed band size : 70 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 85 kDa (possible non-specific binding).

References

ab45814 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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