General notesab94055 is a 293T cell transfected lysate in which Human Monocarboxylic acid transporter 1 has been transiently over-expressed using a pCMV-Monocarboxylic acid transporter 1 plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more details on how the transfected lysate was prepared view preparation notes
BackgroundFunction: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Tissue specificity: Widely expressed in normal and in cancer cells.
Disease: Symptomatic deficiency in lactate transport
Familial hyperinsulinemic hypoglycemia 7
Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.