Human Predicted to work with:
Mouse, Rat, Chimpanzee
Recombinant fragment: MDDRYPALQR AQLRLDFIHA NSTTHSFLFG ALAELLDNAR DAGAERLDVF SVDNEKLQGG FMLCFLDDGC GMSPEEASDI IYFGRSKKRL STLKFIGQYG , corresponding to N terminal amino acids 1 - 100 of Human MORC1 (NP_055244) with a proprietary tag of 26 kDa
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 113 kDa.
Use at an assay dependent dilution.
RelevanceMORC1 is the Human homolog of Mouse MORC and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells.