Overview

  • Product name
  • Description
    Mouse monoclonal to Morphine
  • Specificity
    This antibody has a Kd of 2 nM for morphine and related alkaloids (e.g., codeine, nalorphine, andnaltrexone).
  • Tested applications
    Suitable for: ELISAmore details
  • Immunogen

    Morphine conjugated at the C6 position to bovine serum albumin.

  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause.

Properties

Applications

Our Abpromise guarantee covers the use of ab1060 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
  • Application notes
    Dilute in PBS or medium which is identical to that used in the assay system.
    This antibody may be used inimmunoassays for detection of alkaloid/narcotic drugs
  • Target

    • Relevance
      Morphine is thought to produce reinforcement phenomena via stimulation of mu, delta, and kappa opioid receptors that regulate stress perception, pain control, reward behavior, and neurohormone secretion in reward-relevant brain systems. It has the highest affinity for mu, followed by delta and kappa. Rapid activation of the mu opioid receptor by morphine results in a euphoric phenotype, thus conferring the reinforcing effects of the drug. This activation is accompanied by extracellular dopamine release, which alters several events related to the cAMP signal transduction pathway. Of particular significance is that CREB seems to be modified by morphine, thereby affecting addictive behavioral phenomena, such as withdrawal symptoms.
    • Alternative names
      • Morphine 6 antibody

    References

    This product has been referenced in:
    • Torres OB  et al. A simple nonradioactive method for the determination of the binding affinities of antibodies induced by hapten bioconjugates for drugs of abuse. Anal Bioanal Chem 408:1191-204 (2016). Read more (PubMed: 26677020) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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