The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesDilute in PBS or medium which is identical to that used in the assay system.
This antibody may be used inimmunoassays for detection of alkaloid/narcotic drugs
RelevanceMorphine is thought to produce reinforcement phenomena via stimulation of mu, delta, and kappa opioid receptors that regulate stress perception, pain control, reward behavior, and neurohormone secretion in reward-relevant brain systems. It has the highest affinity for mu, followed by delta and kappa. Rapid activation of the mu opioid receptor by morphine results in a euphoric phenotype, thus conferring the reinforcing effects of the drug. This activation is accompanied by extracellular dopamine release, which alters several events related to the cAMP signal transduction pathway. Of particular significance is that CREB seems to be modified by morphine, thereby affecting addictive behavioral phenomena, such as withdrawal symptoms.
Morphine 6 antibody
References for Anti-Morphine antibody (ab1060)
This product has been referenced in:
Torres OB et al. A simple nonradioactive method for the determination of the binding affinities of antibodies induced by hapten bioconjugates for drugs of abuse. Anal Bioanal Chem408:1191-204 (2016).
Read more (PubMed: 26677020) »