Overview

  • Product nameAnti-Morphine antibody [BDI263]
    See all Morphine primary antibodies
  • Description
    Mouse monoclonal [BDI263] to Morphine
  • SpecificityReacts with Codeine. Reactivity was determined by ELISA with competition assays. Does not react with Nalorphine, Meperidine or Methadone.
  • Tested applicationsSuitable for: ELISAmore details
  • Immunogen

    Morphine-BTG.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.15M PBS, pH 7.6
  • Concentration information loading...
  • PurityProtein A purified
  • Purification notesPurified from acites.
  • ClonalityMonoclonal
  • Clone numberBDI263
  • IsotypeIgG1
  • Light chain typelambda
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab21143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • RelevanceMorphine is thought to produce reinforcement phenomena via stimulation of mu, delta, and kappa opioid receptors that regulate stress perception, pain control, reward behavior, and neurohormone secretion in reward-relevant brain systems. It has the highest affinity for mu, followed by delta and kappa. Rapid activation of the mu opioid receptor by morphine results in a euphoric phenotype, thus conferring the reinforcing effects of the drug. This activation is accompanied by extracellular dopamine release, which alters several events related to the cAMP signal transduction pathway. Of particular significance is that CREB seems to be modified by morphine, thereby affecting addictive behavioral phenomena, such as withdrawal symptoms.
  • Alternative names
    • Morphine 6 antibody

References for Anti-Morphine antibody [BDI263] (ab21143)

This product has been referenced in:
  • Jalah R  et al. Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM197 carriers. Bioconjug Chem 26:1041-53 (2015). ELISA ; Mouse . Read more (PubMed: 25970207) »
  • Matyas GR  et al. Facial recognition of heroin vaccine opiates: type 1 cross-reactivities of antibodies induced by hydrolytically stable haptenic surrogates of heroin, 6-acetylmorphine, and morphine. Vaccine 32:1473-9 (2014). ELISA . Read more (PubMed: 24486371) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"