Mouse Adipose Triglyceride Lipase (phospho S406) peptide (ab174058)

Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab174058 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity
    > 70 % Ammonium Sulphate Precipitation.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Information available upon request.

General Info

  • Alternative names
    • 1110001C14Rik
    • Adipose triglyceride lipase
    • ATGL
    • ATGL DESNUTRIN
    • Calcium independent phospholipase A2
    • Calcium-independent phospholipase A2
    • Desnutrin
    • EC 3.1.1.3
    • FP17548
    • IPLA2 zeta
    • IPLA2-zeta
    • Mutant patatin like phospholipase domain containing 2
    • Patatin like phospholipase domain containing 2
    • PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2
    • Patatin-like phospholipase domain-containing protein 2
    • PEDF R
    • PHOSPHOLIPASE A2 CALCIUM INDEPENDENT ZETA
    • Pigment epithelium derived factor
    • Pigment epithelium-derived factor
    • plpl
    • plpl2
    • PLPL2_HUMAN
    • Pnpla2
    • Transport secretion protein 2
    • Transport secretion protein 2.2
    • Transport-secretion protein 2
    • Triglyceride hydrolase
    • TTS 2.2
    • TTS2
    • TTS2.2
    • ZETA
    see all
  • Function
    Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
  • Tissue specificity
    Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level).
  • Pathway
    Glycerolipid metabolism; triacylglycerol degradation.
  • Involvement in disease
    Note=Genetic variations in PNPLA2 may be associated with risk of diabetes mellitus type 2.
    Defects in PNPLA2 are the cause of neutral lipid storage disease with myopathy (NLSDM) [MIM:610717]; also known as neutral lipid storage disease without ichthyosis. NSLDM is a neutral lipid storage disorder (NLSD) with myopathy but without ichthyosis. NLSDs are characterized by the presence of triglyceride-containing cytoplasmic droplets in leukocytes and in other tissues, including bone marrow, skin, and muscle. Individuals with NLSDM did not show obesity, in spite of a defect in triglyceride degradation in fibroblasts and in marked triglyceride storage in liver, muscles, and other visceral cells.
  • Sequence similarities
    Contains 1 patatin domain.
  • Developmental stage
    Induced during differentiation of primary preadipocytes to adipocytes. Expression increased from fetal to adult in retinal pigment epithelium.
  • Cellular localization
    Lipid droplet. Cell membrane.
  • Information by UniProt

References

ab174058 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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