The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-AP3B2 antibody (ab48269)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Adapter-related protein complex 3 subunit beta-2
Adaptor protein complex AP-3 subunit beta-2
Adaptor related protein complex 3 beta 2 subunit
AP 3 complex subunit beta 2
AP-3 complex subunit beta-2
Clathrin assembly protein complex 3 beta 2 large chain
Clathrin assembly protein complex 3 beta-2 large chain
Neuron specific vesicle coat protein and cerebellar degeneration antigen
Neuron-specific vesicle coat protein beta-NAP
Neuronal adaptin like protein beta subunit
FunctionSubunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.
Tissue specificityExpression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression).
Sequence similaritiesBelongs to the adaptor complexes large subunit family.
Developmental stageExpressed from early in development through adulthood.
Cellular localizationGolgi apparatus. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Golgi apparatus. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.