Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Bile acid receptor
Farnesoid X activated receptor
Farnesoid X receptor
Farnesoid X-activated receptor
Farnesol receptor HRR 1
Farnesol receptor HRR-1
Farnesol receptor HRR1
Nuclear receptor subfamily 1 group H member 4
Retinoid X receptor interacting protein 14
Retinoid X receptor-interacting protein 14
RXR interacting protein 14
RXR-interacting protein 14
FunctionLigand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.