Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab27843 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • Calcium/calmodulin dependent protein kinase (CaM kinase) II beta
    • Calcium/calmodulin dependent protein kinase II beta
    • Calcium/calmodulin dependent protein kinase IIB
    • Calcium/calmodulin dependent protein kinase type II beta chain
    • calcium/calmodulin-dependent protein kinase II beta
    • Calcium/calmodulin-dependent protein kinase type II subunit beta
    • CAM 2
    • CaM kinase II beta chain
    • CaM kinase II beta subunit
    • CaM kinase II subunit beta
    • CaM-kinase II beta chain
    • CAM2
    • CAMK 2
    • CAMK 2B
    • CaMK II beta subunit
    • CaMK II subunit beta
    • CaMK-II subunit beta
    • CAMK2
    • CaMK2 beta
    • Camk2b
    • CAMKB
    • CaMKII beta subunit
    • CaMKIIB
    • KCC2B_HUMAN
    • MGC29528
    • Proline rich calmodulin dependent protein kinase
    • proline rich calmodulin-dependent protein kinase
    see all
  • Function
    CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.
  • Tissue specificity
    Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 1 protein kinase domain.
  • Information by UniProt

References

ab27843 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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