The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-CEBP Beta antibody [18F8] (ab15049)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
C EBP beta
C/EBP related protein 2
CCAAT Enhancer Binding Protein beta
CCAAT/enhancer-binding protein beta
Interleukin 6 dependent binding protein
Liver activator protein
Liver enriched transcriptional activator
Nuclear factor NF IL6
Nuclear factor NF-IL6
Silencer factor B
Transcription factor 5
FunctionImportant transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation.
Tissue specificityExpressed at low levels in the lung, kidney and spleen.
Sequence similaritiesBelongs to the bZIP family. C/EBP subfamily. Contains 1 bZIP domain.
Domainthe 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Post-translational modificationsSumoylated by polymeric chains of SUMO2 or SUMO3.