SequenceThis sequence is highly conserved in rat paxillin and is also found in all three isoforms, alpha, beta and gamma. There is low homology between this sequence and the conserved sequence site in human paxillin (around Serine 85).
FunctionCytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
Sequence similaritiesBelongs to the paxillin family. Contains 4 LIM zinc-binding domains.
Post-translational modificationsPhosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.