Single immunoglobulin and toll interleukin 1 receptor (TIR) domain
Single immunoglobulin and toll interleukin 1 receptor domain
Single immunoglobulin domain containing IL1R related protein
Single immunoglobulin domain IL1R1 related
Single immunoglobulin domain-containing IL1R-related protein
Toll/interleukin 1 receptor 8
Toll/interleukin-1 receptor 8
FunctionActs as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Tissue specificityMainly expressed in epithelial tissues such as kidney, lung and gut.
Sequence similaritiesBelongs to the interleukin-1 receptor family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TIR domain.