Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Mouse

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39849 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SIGIRR antibody (ab25875)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Ig IL1 related receptor
    • MGC110992
    • SIGIR_HUMAN
    • SIGIRR
    • Single Ig IL 1 related receptor
    • Single Ig IL-1-related receptor
    • Single Ig IL-1R-related molecule
    • Single Ig IL1R Related Molecule
    • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain
    • Single immunoglobulin and toll interleukin 1 receptor domain
    • Single immunoglobulin domain containing IL1R related protein
    • Single immunoglobulin domain IL1R1 related
    • Single immunoglobulin domain-containing IL1R-related protein
    • TIR 8
    • TIR8
    • Toll/interleukin 1 receptor 8
    • Toll/interleukin-1 receptor 8
    see all
  • Function
    Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • Tissue specificity
    Mainly expressed in epithelial tissues such as kidney, lung and gut.
  • Sequence similarities
    Belongs to the interleukin-1 receptor family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 TIR domain.
  • Cellular localization
    Membrane.
  • Information by UniProt

References

ab39849 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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