Biological descriptionI1 Imidazoline receptor and α2 adrenergic agonist. Displays 4-fold greater affinity at I1 receptors than α2 receptors. Centrally active. Displays antihypertensive action.
Chemical name4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine hydrochloride
Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Moxonidine hydrochloride (ab120789)
This product has been referenced in:
Mukaddam-Daher S et al. Hemodynamic and cardiac effects of chronic eprosartan and moxonidine therapy in stroke-prone spontaneously hypertensive rats. Hypertension53:775-81 (2009).
Read more (PubMed: 19273740) »
El-Ayoubi R et al. Imidazoline receptors but not alpha 2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment. J Pharmacol Exp Ther310:446-51 (2004).
Read more (PubMed: 15075383) »
Schäfer U et al. Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors. J Pharmacol Exp Ther303:1163-70 (2002).
Read more (PubMed: 12438540) »