Overview

  • Product nameAnti-MRC2 antibody
    See all MRC2 primary antibodies
  • Description
    Rabbit polyclonal to MRC2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 797-827 of Human MRC2 (NP_006030.2).

  • Positive control
    • NCI-H460 cell line lysates.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesPurified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab124250 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 167 kDa.

Target

  • FunctionMay play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).
  • Tissue specificityUbiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
  • Sequence similaritiesContains 8 C-type lectin domains.
    Contains 1 fibronectin type-II domain.
    Contains 1 ricin B-type lectin domain.
  • DomainC-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.
    Fibronectin type-II domain mediates collagen-binding.
    Ricin B-type lectin domain contacts with the second C-type lectin domain.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C-type lectin domain family 13 member E antibody
    • C-type mannose receptor 2 antibody
    • CD 280 antibody
    • CD280 antibody
    • CD280 antigen antibody
    • CLEC 13E antibody
    • CLEC13E antibody
    • ENDO 180 antibody
    • ENDO180 antibody
    • Endocytic receptor (macrophage mannose receptor family) antibody
    • Endocytic receptor 180 antibody
    • FLJ35911 antibody
    • KIAA0709 antibody
    • Macrophage mannose receptor 2 antibody
    • Mannose receptor C type 2 antibody
    • MRC 2 antibody
    • MRC2 antibody
    • MRC2_HUMAN antibody
    • UPAR-associated protein antibody
    • UPARAP antibody
    • Urokinase plasminogen activator receptor associated protein antibody
    • Urokinase receptor associated protein antibody
    • Urokinase receptor-associated protein antibody
    • Urokinase-type plasminogen activator receptor-associated protein antibody
    see all

Anti-MRC2 antibody images

  • Anti-MRC2 antibody (ab124250) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

    Predicted band size : 167 kDa

References for Anti-MRC2 antibody (ab124250)

ab124250 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"