Overview

  • Product name
  • Description
    Rabbit polyclonal to MRF
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant fragment
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to Mouse MRF.

Properties

Applications

Our Abpromise guarantee covers the use of ab96444 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 124 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA 1/2000 - 1/5000.

Target

  • Function
    Transcription regulator required for expression of central nervous system (CNS) myelin genes such as MBP and MOG, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Probably acts as a transcription factor that directly binds DNA and activates expression of CNS myelin genes.
  • Tissue specificity
    Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal ganglion and liver. Weakly expressed in cerebellum and retina.
  • Sequence similarities
    Belongs to the MRF family.
    Contains 1 NDT80 DNA-binding domain.
  • Domain
    A transmembrane region is predicted by sequence analysis tools. However, the protein is nuclear and probably acts as a transcription factor. It is therefore unclear whether the predicted transmembrane region is a hydrophobic region that does not insert into membranes or whether it is a real transmembrane region that may be cleaved when acting as transcription regulator.
  • Cellular localization
    Membrane. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • C11orf9 antibody
    • Chromosome 11 open reading frame 9 antibody
    • GM1804 antibody
    • GM98 antibody
    • KIAA0954 antibody
    • MGC10781 antibody
    • MRF antibody
    • MRF_HUMAN antibody
    • Myelin gene regulatory factor antibody
    • Ndt80 antibody
    see all

References

ab96444 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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